Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system

Détails

ID Serval
serval:BIB_88E1A7132F2E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system
Périodique
Critical Reviews in Immunology
Auteur(s)
Calandra  T., Bucala  R.
ISSN
1040-8401 (Print)
Statut éditorial
Publié
Date de publication
1997
Volume
17
Numéro
1
Pages
77-88
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Résumé
Originally described as a T lymphocyte-derived factor that inhibited the random migration of macrophages, the protein known as macrophage migration inhibitory factor (MIF) was an enigmatic cytokine for almost 3 decades. In recent years, the discovery of MIF as a product of the anterior pituitary gland and the cloning and expression of bioactive, recombinant MIF protein have led to the definition of its critical biological role in vivo. MIF has the unique property of being released from macrophages and T lymphocytes that have been stimulated by glucocorticoids. Once released, MIF overcomes the inhibitory effects of glucocorticoids on TNF alpha, IL-1 beta, IL-6, and IL-8 production by LPS-stimulated monocytes in vitro and suppresses the protective effects of steroids against lethal endotoxemia in vivo. MIF also antagonizes glucocorticoid inhibition of T-cell proliferation in vitro by restoring IL-2 and IFN-gamma production. This observation has identified a pivotal role for MIF within the immune system and fills an important gap in our understanding of the control of inflammatory and immune responses. Glucocorticoids have long been considered to be an integral component of the stress response to infection or tissue invasion and serve to modulate inflammatory and immune responses. MIF is the first mediator to be identified that can counter-regulate the inhibitory effects of glucocorticoids and thus plays a critical role in the host control of inflammation and immunity.
Mots-clé
Amino Acid Sequence Animals Cattle Chickens Gene Expression Regulation Glucocorticoids/*antagonists & inhibitors/immunology/pharmacology Humans Interferon Type II/immunology Interleukins/immunology Lipopolysaccharides Macrophage Migration-Inhibitory Factors/chemistry/genetics/*immunology Macrophages/immunology/metabolism Mice Molecular Sequence Data Molecular Structure Pituitary Gland/immunology/metabolism Rats Sequence Homology, Amino Acid Shock, Septic/immunology/metabolism T-Lymphocytes/immunology/metabolism Tumor Necrosis Factor-alpha/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 14:28
Dernière modification de la notice
20/08/2019 15:47
Données d'usage