Strategies for improving outcomes in NSCLC: a look to the future.

Détails

ID Serval
serval:BIB_88D1B61C50DE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Strategies for improving outcomes in NSCLC: a look to the future.
Périodique
Lung Cancer (amsterdam, Netherlands)
Auteur⸱e⸱s
Stahel R., Peters S., Baas P., Brambilla E., Cappuzzo F., De Ruysscher D., Eberhardt W.E., Felip E., Fennell D., Marchetti A., Paz-Ares L., Adjei A.A.
ISSN
1872-8332 (Electronic)
ISSN-L
0169-5002
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
82
Numéro
3
Pages
375-382
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish Document Type: Review
Résumé
Advances in the management of non-small cell lung cancer (NSCLC) over the past 30 years have led to small increases in 5-year survival rates across Europe, though further improvements may require new treatment strategies. In order to improve efficiency and reduce the cost of development, future trials for new targeted agents in NSCLC should aim to recruit patients on the basis of tumour biology rather than clinical characteristics. However, identification of predictive biomarkers is required to maximise the benefits of new approaches and expedite the drug development process. Nevertheless, the NSCLC landscape is changing rapidly, and recent improvements in our understanding of the molecular biology of the disease will help in the identification of novel targeted agents as well as assisting in the development of personalised strategies for the numerous small subsets of defined NSCLC. Progress in imaging and treatment delivery is also likely to improve outcomes for patients with the disease. This article outlines recent progress in the treatment of NSCLC, identifies current challenges and describes proposals for improving the future management of the disease. It is hoped that implementation of some of these strategies will go some way to improving the outlook for patients with NSCLC.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/01/2014 16:49
Dernière modification de la notice
20/08/2019 14:47
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