Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Détails

ID Serval
serval:BIB_88D1022A93C0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Asrih M., Jornayvaz F.R.
ISSN
1872-8057 (Electronic)
ISSN-L
0303-7207
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
418 Pt 1
Pages
55-65
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western countries, affecting more than 30% of the general population. NAFLD encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. There is accumulating evidence supporting an association between NAFLD and MetS. Indeed, NAFLD is recognized as the liver manifestation of MetS. Insulin resistance is increasingly recognized as a key factor linking MetS and NAFLD. Insulin resistance is associated with excessive fat accumulation in ectopic tissues, such as the liver, and increased circulating free fatty acids, which can further promote inflammation and endoplasmic reticulum stress. This in turn aggravates and maintains the insulin resistant state, constituting a vicious cycle. Importantly, evidence shows that most of the patients developing NAFLD present at least one of the MetS traits. This review will define MetS and NAFLD, provide an overview of the common pathophysiological mechanisms linking MetS and NAFLD, and give a perspective regarding treatment of these ever growing metabolic diseases.
Mots-clé
Animals, Diabetes Mellitus, Type 2/metabolism, Diabetes Mellitus, Type 2/pathology, Humans, Insulin Resistance/physiology, Liver/metabolism, Liver/pathology, Metabolic Syndrome X/metabolism, Metabolic Syndrome X/pathology, Non-alcoholic Fatty Liver Disease/metabolism, Non-alcoholic Fatty Liver Disease/pathology, Obesity/metabolism, Obesity/pathology
Pubmed
Web of science
Création de la notice
10/09/2015 12:57
Dernière modification de la notice
20/08/2019 15:47
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