Fongemies a Candida. [Candida fungemia]

Détails

ID Serval
serval:BIB_88ABCFAF8A20
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fongemies a Candida. [Candida fungemia]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur⸱e⸱s
Zanetti  G., Calandra  T., de Muralt  B., Bille  J., Glauser  M. P.
ISSN
0036-7672
Statut éditorial
Publié
Date de publication
09/1989
Peer-reviewed
Oui
Volume
119
Numéro
36
Pages
1213-8
Notes
English Abstract
Journal Article --- Old month value: Sep 9
Résumé
From 1980 to 1986, 52 patients presented with an episode of fungemia due to Candida species at the Centre Hospitalier Universitaire Vaudois (representing 2% of the patients with positive blood cultures). In 51 of the 52 patients (98%) the infection was nosocomial, occurring after a median hospital stay of 24 days (range 4-250 days). Only 36 patients (69%) presented with an underlying condition (neoplasms in 18 patients, alcoholism in 7, diabetes in 6, immunosuppressive therapy in 5). In 19 patients (37%) an episode of bacteremia occurred prior to fungemia (median time 14 days, range 1-70 days). Candida albicans was the most commonly isolated species (71%). In 50 patients (96%) the episode of fungemia was associated with a significant, although nonspecific, clinical impairment. The digestive tract (38%) and N intravascular catheter (31%) were the two most common portals of entry for the fungemia. 32 patients (62%) received specific antifungal therapy consisting of amphotericin B in 29 patients (median total dose 450 mg, administered either alone or in association) or of ketoconazole in 3 patients. The global mortality was 46% and the fungemia-related mortality was 21%. Global and fungemia-related mortalities were significantly higher in patients not treated with antifungals than in those treated with them (87% versus 30%, p less than 0.001, and 47% versus 11%, p = 0.01 respectively).
Mots-clé
Adolescent Adult Aged Aged, 80 and over Amphotericin B/therapeutic use Blood/microbiology Candida albicans/isolation & purification Candidiasis/*blood/drug therapy/etiology Child Child, Preschool Cross Infection/microbiology Female Humans Ketoconazole/therapeutic use Male Middle Aged Retrospective Studies
Pubmed
Web of science
Création de la notice
21/01/2008 10:04
Dernière modification de la notice
20/08/2019 14:47
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