Neuronal cell death and synaptic pruning driven by spike-timing dependent plasticity

Détails

ID Serval
serval:BIB_88780DF54108
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuronal cell death and synaptic pruning driven by spike-timing dependent plasticity
Périodique
Lecture Notes in Computer Science
Auteur(s)
Iglesias  J., Villa  A. E. P.
ISSN
0302-9743
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
4131
Pages
953-962
Langue
anglais
Notes
Iglesias2006953
Résumé
The embryonic nervous system is refined over the course of development as a result of two main processes: apoptosis (programmed cell death) and selective axon pruning. We simulated a large scale spiking neural network characterized by an initial apoptotic phase, driven by an excessive firing rate, followed by the onset of spike-timing-dependent plastiticity (STDP), driven by spatiotemporal patterns of stimulation. In the apoptotic phase the cell death affected the inhibitory more than the excitatory units. The network activity stabilized such that recurrent preferred firing sequences appeared along the STDP phase, thus suggesting the emergence of cell assemblies from large randomly connected networks.
Mots-clé
Neural-networks, POEtic tissue, Cortex, Dynamics, Density
Web of science
Création de la notice
23/08/2010 16:52
Dernière modification de la notice
20/08/2019 15:47
Données d'usage