Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development

Détails

ID Serval
serval:BIB_8877F363C213
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
Périodique
Journal of Experimental Medicine
Auteur(s)
Luther  S. A., Ansel  K. M., Cyster  J. G.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
05/2003
Volume
197
Numéro
9
Pages
1191-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: May 5
Résumé
Lymphoid tissue development is associated with local accumulation of CD4+ CD3- IL-7R alpha hi hematopoietic cells that deliver lymphotoxin (LT)alpha 1 beta 2 signals to resident stromal cells. Previous studies have established an important role for CXCL13 (BLC) in the development of Peyer's patches (PP) and some peripheral lymph nodes (LNs), but the chemokine requirements for several LN types, including mesenteric LNs, remain undefined. Using CXCL13-/- mice that additionally carry the paucity of LN T cell mutation (plt/plt), we discovered that CCR7 ligands function in peripheral LN development. We also tested for a genetic interaction during LN development between CXCL13 and a cytokine receptor required in PP development, IL-7R alpha. Mice deficient for both CXCL13 and IL-7R alpha displayed a striking absence of LNs, including mesenteric LNs. These data extend the role of CXCL13 to the development of all LNs and establish a previously unappreciated role for IL-7R alpha in this process. Both circulating and LN CD4+ CD3- IL-7R alpha hi cells are shown to express LT alpha 1 beta 2 in an IL-7R alpha-dependent manner. Furthermore, CXCL13 was found to be sufficient to mediate CD4+ CD3- IL-7R alpha hi cell recruitment in vivo to an ectopic site. These findings indicate that CXCL13 and CCR7 ligands promote accumulation of CD4+ CD3- IL-7R alpha hi cells, delivering IL-7R alpha-dependent LT alpha 1 beta 2 signals critical for LN development.
Mots-clé
Animals Base Sequence Chemokines, CXC/genetics/*physiology DNA Primers Islets of Langerhans/metabolism Ligands Lymph Nodes/*growth & development Mice Mice, Inbred C57BL Receptors, Chemokine/metabolism/*physiology Receptors, Interleukin-7/genetics/*physiology Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:04
Dernière modification de la notice
20/08/2019 15:47
Données d'usage