Thrombogenicity of deflated intraaortic balloon: impact of heparin coating

Détails

ID Serval
serval:BIB_885C1F7E92BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Thrombogenicity of deflated intraaortic balloon: impact of heparin coating
Périodique
Artificial Organs
Auteur⸱e⸱s
Mueller  X. M., Tevaearai  H. T., Hayoz  D., von Segesser  L. K.
ISSN
0160-564X (Print)
Statut éditorial
Publié
Date de publication
02/1999
Volume
23
Numéro
2
Pages
195-8
Notes
Journal Article --- Old month value: Feb
Résumé
In a calf model, 3 standard and 3 heparin coated intraaortic balloons (IAB) were inserted and left deflated in the descending aorta during 20 min to simulate balloon rupture. At the end of the experiment, the IAB were examined, and 3 samples of each were collected for scanning electron microscopy (SEM) analysis. None of the heparin coated IAB showed any sign of clot or deposit whereas all 3 standard IAB exhibited clots. SEM revealed no deposit on the heparin coated samples while 8 of the 9 standard samples disclosed deposits (p < 0.001). Morphometrically, 16.1+/-21.4% of the surfaces of the standard samples were covered with deposits whereas all the heparin coated samples were free (p = 0.004). The presence of clots on every standard IAB supports the hypothesis that other than local factors of the insertion site can play a role in the vascular complications of IAB. The absence of clots and deposits on the heparin coated IAB suggests a promising role of such devices in circumventing the tendency of clot formation on deflated balloons while avoiding the drawback of systemic anticoagulation.
Mots-clé
Animals Cattle *Coated Materials, Biocompatible Equipment Failure *Heparin Intra-Aortic Balloon Pumping/*adverse effects Microscopy, Electron, Scanning Thrombosis/etiology/*prevention & control
Pubmed
Web of science
Création de la notice
17/01/2008 16:38
Dernière modification de la notice
20/08/2019 14:47
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