Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-γ expression.

Détails

ID Serval
serval:BIB_884E9C223D71
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-γ expression.
Périodique
Peptides
Auteur⸱e⸱s
Rosmaninho-Salgado J., Marques A.P., Estrada M., Santana M., Cortez V., Grouzmann E., Cavadas C.
ISSN
1873-5169 (Electronic)
ISSN-L
0196-9781
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
37
Numéro
1
Pages
49-54
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
We evaluated the effects of dipeptidyl peptidase-IV (DPPIV), and its inhibitor, vildagliptin, on adipogenesis and lipolysis in a pre-adipocyte murine cell line (3T3-L1). The exogenous rDPPIV increased lipid accumulation and PPAR-γ expression, whereas an inhibitor of DPPIV, the anti-diabetic drug vildagliptin, suppresses the stimulatory role of DPPIV on adipogenesis and lipid accumulation, but had no effect on lipolysis. NPY immunoneutralization or NPY Y(2) receptor blockage inhibited DPPIV stimulatory effects on lipid accumulation, collectively, indicating that DPPIV has an adipogenic effect through NPY cleavage and subsequent NPY Y(2) activation. Vildagliptin inhibits PPAR-γ expression and lipid accumulation without changing lipolysis, suggesting that this does not impair the ability of adipose tissue to store triglycerides inside lipid droplets. These data indicate that DPPIV and NPY interact on lipid metabolism to promote adipose tissue depot.
Pubmed
Web of science
Création de la notice
26/10/2012 18:23
Dernière modification de la notice
20/10/2020 10:12
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