Cancer immunotherapy drives implementation science in oncology.

Détails

ID Serval
serval:BIB_87B192022437
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Cancer immunotherapy drives implementation science in oncology.
Périodique
Human Vaccines and Immunotherapeutics
Auteur(s)
Speiser D.E., Flatz L.
ISSN
2164-554X (Electronic)
ISSN-L
2164-5515
Statut éditorial
Publié
Date de publication
2014
Volume
10
Numéro
11
Pages
3107-3110
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Editorial Material
Résumé
Cancer immunotherapy has come a long way. The hope that immunological approaches may help cancer patients has sparked many initiatives in research and development (R&D). For many years, progress was modest and disappointments were frequent. Today, the increasing scientific and medical knowledge has established a solid basis for improvements. Considerable clinical success was first achieved for patients with hematological cancers. More recently, immunotherapy has entered center stage in the development of novel therapies against solid cancers. Together with R&D in angiogenesis, the field of immunology has fundamentally extended the scientific scope, which has evolved from a cancer-cell-centered view to a comprehensive and integrated vision of tumor biology. Current R&D is focused on a large array of possible disease mechanisms, driven by cancer cells, and amplified by tumor stroma, inflammatory and immunological actors, blood and lymph vessels, and the "macroenvironment," i.e. systemic mechanisms of the host, particularly of the haematopoietic system. Contrasting to this large spectrum of pathophysiological events promoting tumor growth, only a small number of biological mechanisms, namely of the immune system, have the potential to counteract tumor growth. They are of prime interest because therapeutic enhancement may result in clinical benefit for patients. This special issue is dedicated to immunotherapeutics against cancer, with particular emphasis on vaccination and combination therapies, providing updates and extended insight in this booming field.
Pubmed
Web of science
Création de la notice
13/03/2015 18:53
Dernière modification de la notice
20/08/2019 14:46
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