T1-Based Synthetic Magnetic Resonance Contrasts Improve Multiple Sclerosis and Focal Epilepsy Imaging at 7 T.

Détails

ID Serval
serval:BIB_87ACAA2EFB01
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T1-Based Synthetic Magnetic Resonance Contrasts Improve Multiple Sclerosis and Focal Epilepsy Imaging at 7 T.
Périodique
Investigative radiology
Auteur⸱e⸱s
Massire A., Seiler C., Troalen T., Girard O.M., Lehmann P., Brun G., Bartoli A., Audoin B., Bartolomei F., Pelletier J., Callot V., Kober T., Ranjeva J.P., Guye M.
ISSN
1536-0210 (Electronic)
ISSN-L
0020-9996
Statut éditorial
Publié
Date de publication
01/02/2021
Peer-reviewed
Oui
Volume
56
Numéro
2
Pages
127-133
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Ultra-high field magnetic resonance imaging (MRI) (≥7 T) is a unique opportunity to improve the clinical diagnosis of brain pathologies, such as multiple sclerosis or focal epilepsy. However, several shortcomings of 7 T MRI, such as radiofrequency field inhomogeneities, could degrade image quality and hinder radiological interpretation. To address these challenges, an original synthetic MRI method based on T1 mapping achieved with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) sequence was developed. The radiological quality of on-demand T1-based contrasts generated by this technique was evaluated in multiple sclerosis and focal epilepsy imaging at 7 T.
This retrospective study was carried out from October 2017 to September 2019 and included 21 patients with different phenotypes of multiple sclerosis and 35 patients with focal epilepsy who underwent MRI brain examinations using a whole-body investigative 7 T magnetic resonance system. The quality of 2 proposed synthetic contrast images were assessed and compared with conventional images acquired at 7 T using the MP2RAGE sequence by 4 radiologists, evaluating 3 qualitative criteria: signal homogeneity, contrast intensity, and lesion visualization. Statistical analyses were performed on reported quality scores using Wilcoxon rank tests and further multiple comparisons tests. Intraobserver and interobserver reliabilities were calculated as well.
Radiological quality scores were reported higher for synthetic images when compared with original images, regardless of contrast, pathologies, or raters considered, with significant differences found for all 3 criteria (P < 0.0001, Wilcoxon rank test). None of the 4 radiologists ever rated a synthetic image "markedly worse" than an original image. Synthetic images were rated slightly less satisfying for only 3 epileptic patients, without precluding lesion identification.
T1-based synthetic MRI with the MP2RAGE sequence provided on-demand contrasts and high-quality images to the radiologist, facilitating lesion visualization in multiple sclerosis and focal epilepsy, while reducing the magnetic resonance examination total duration by removing an additional sequence.
Mots-clé
Brain/diagnostic imaging, Epilepsies, Partial/diagnostic imaging, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Multiple Sclerosis/diagnostic imaging, Retrospective Studies
Pubmed
Web of science
Création de la notice
09/09/2020 10:56
Dernière modification de la notice
05/12/2023 7:05
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