Effect of progression of left ventricular hypertrophy on coronary artery dimensions in aortic valve disease

Détails

ID Serval
serval:BIB_87284962E9C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of progression of left ventricular hypertrophy on coronary artery dimensions in aortic valve disease
Périodique
Journal of the American College of Cardiology
Auteur(s)
Villari  B., Hess  O. M., Moccetti  D., Vassalli  G., Krayenbuehl  H. P.
ISSN
0735-1097 (Print)
Statut éditorial
Publié
Date de publication
11/1992
Volume
20
Numéro
5
Pages
1073-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 1
Résumé
OBJECTIVES. The effect of progression of left ventricular hypertrophy on coronary artery dimensions was studied in patients with aortic valve disease. METHODS. Cross-sectional area of the left and right coronary arteries was determined by quantitative coronary arteriography in 12 control subjects and in 10 patients with aortic valve disease at baseline and after a follow-up period of 66 months. RESULTS. The cross-sectional area of the left coronary artery was larger in patients with aortic valve disease than in control subjects (left anterior descending artery 13 vs. 8 mm2, p < 0.001; left circumflex artery 13 vs. 6 mm2, p < 0.001). At the follow-up examination, cross-sectional area of the left coronary artery increased (left anterior descending artery 17 mm2, p < 0.01 vs. baseline; left circumflex artery 15 mm2, p < 0.01 vs. baseline). The cross-sectional area of the right coronary artery was not different in patients with aortic valve disease from that in control subjects. Left ventricular muscle mass was larger in patients with aortic valve disease both at baseline (269 g, p < 0.001) and after follow-up examination (339 g, p < 0.001) than in control subjects (136 g). The appropriateness of coronary artery size with respect to muscle mass was evaluated by normalizing cross-sectional area of the left coronary artery (left anterior descending plus left circumflex artery) per 100 g of left ventricular muscle mass (mm2/100 g). This index was 10.9 mm2/100 g in control subjects, and decreased in subjects with aortic valve disease from 10.3 mm2/100 g at baseline to 8.6 mm2/100 g at the follow-up measurement (p < 0.05 vs. control values). CONCLUSIONS. In patients with aortic valve disease, the progression of left ventricular hypertrophy is associated with an increase in left anterior descending and left circumflex coronary artery dimensions, whereas the size of the right coronary artery remains unchanged. Despite the enlargement of the left coronary artery, the cross-sectional area of the left coronary artery per 100 g of left ventricular muscle mass decreased. Hence, the increase in coronary artery size appears to be inadequate when the severity of left ventricular hypertrophy increases.
Mots-clé
Adult Aged Analysis of Variance *Aortic Valve Chi-Square Distribution Coronary Angiography Coronary Vessels/*pathology Follow-Up Studies Heart Catheterization Heart Valve Diseases/diagnosis/epidemiology/physiopathology Heart Ventricles/radiography Hemodynamic Processes Humans Hypertrophy, Left Ventricular/*diagnosis/epidemiology/physiopathology Middle Aged Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 10:32
Dernière modification de la notice
20/08/2019 14:46
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