Neuropathological analysis of lacunes and microvascular lesions in late-onset depression.
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_871F1D83632C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neuropathological analysis of lacunes and microvascular lesions in late-onset depression.
Périodique
Neuropathology and Applied Neurobiology
ISSN
1365-2990[electronic], 0305-1846[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
36
Numéro
7
Pages
661-672
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
M. Santos, G. Gold, E. Kövari, F. R. Herrmann, P. R. Hof, C. Bouras and P. Giannakopoulos (2010) Neuropathology and Applied Neurobiology36, 661-672
Neuropathological analysis of lacunes and microvascular lesions in late-onset depression Aims: Previous neuropathological studies documented that small vascular and microvascular pathology is associated with cognitive decline. More recently, we showed that thalamic and basal ganglia lacunes are associated with post-stroke depression and may affect emotional regulation. The present study examines whether this is also the case for late-onset depression. Methods: We performed a detailed analysis of small macrovascular and microvascular pathology in the post mortem brains of 38 patients with late-onset major depression (LOD) and 29 healthy elderly controls. A clinical diagnosis of LOD was established while the subjects were alive using the DSM-IV criteria. Additionally, we retrospectively reviewed all charts for the presence of clinical criteria of vascular depression. Neuropathological evaluation included bilateral semi-quantitative assessment of lacunes, deep white matter and periventricular demyelination, cortical microinfarcts and both focal and diffuse gliosis. The association between vascular burden and LOD was investigated using Fisher's exact test and univariate and multivariate logistic regression models. Results: Neither the existence of lacunes nor the presence of microvascular ischaemic lesions was related to occurrence of LOD. Similarly, there was no relationship between vascular lesion scores and LOD. This was also the case within the subgroup of LOD patients fulfilling the clinical criteria for vascular depression. Conclusions: Our results challenge the vascular depression hypothesis by showing that neither deep white matter nor periventricular demyelination is associated with LOD. In conjunction with our previous observations in stroke patients, they also imply that the impact of lacunes on mood may be significant solely in the presence of acute brain compromise.
Pubmed
Web of science
Création de la notice
23/11/2010 15:48
Dernière modification de la notice
20/08/2019 15:46