Depression in Parkinson's disease.

Détails

ID Serval
serval:BIB_86DF18061E09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Depression in Parkinson's disease.
Périodique
Canadian Journal of Neurological Sciences
Auteur(s)
Jasinska-Myga B., Putzke J.D., Wider C., Wszolek Z.K., Uitti R.J.
ISSN
0317-1671[print], 0317-1671[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
37
Numéro
1
Pages
61-66
Langue
anglais
Résumé
OBJECTIVE: To examine predictive factors associated with onset of depression among individuals diagnosed with Parkinson's disease (PD).
BACKGROUND: Depression may precede or follow symptomatic parkinsonism in PD. It is frequently treatable but often overlooked.
METHODS: The clinical series comprised 685 individuals who were diagnosed with PD and followed by one neurologist (RJU) from 1994 to 2007. The primary outcome was time to depression following the onset of PD. Diagnosis of depression was based on clinical assessment of depressive symptoms from patients (and spouse/family/caregiver) and antidepressant usage. A number of demographic, historical and clinical predictive factors were examined, including gender, age at symptomatic onset, disease duration, onset characteristics, clinical ratings, antiparkinsonian medications, cognitive status, depression history, and familial history of PD and other neurodegenerative disorders.
RESULTS: Seventy-two percent of patients developed depression within ten years of symptomatic PD onset, and the mean time to depression was 7.9 years (median: 5.7 years). Factors associated with depression included longer PD duration, greater impairment in activities of daily living, and positive family history of motor neuron disease (MND).
CONCLUSIONS: A high rate of individuals with PD develop depressive symptoms during the course of the disease. Based on first clinic visit characteristics, most factors examined were not helpful in identifying individuals with an increased risk of depression. However, disease duration, functional limitations and family history of MND should lead clinicians to an increased vigilance for identifying depression.
Mots-clé
Age Factors, Age of Onset, Aged, Aged, 80 and over, Antiparkinson Agents/therapeutic use, Depression/complications, Depression/mortality, Female, Follow-Up Studies, Humans, Male, Parkinson Disease/complications, Parkinson Disease/drug therapy, Predictive Value of Tests, Retrospective Studies, Sex Factors, Survival Analysis
Pubmed
Création de la notice
24/09/2010 17:57
Dernière modification de la notice
20/08/2019 14:46
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