Steele-Richardson-Olszewski syndrome. Brain energy metabolism, blood flow and fluorodopa uptake measured by positron emission tomography.

Détails

ID Serval
serval:BIB_86A2635946A7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Steele-Richardson-Olszewski syndrome. Brain energy metabolism, blood flow and fluorodopa uptake measured by positron emission tomography.
Périodique
Brain
Auteur⸱e⸱s
Leenders K.L., Frackowiak R.S., Lees A.J.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1988
Volume
111 ( Pt 3)
Pages
615-630
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Brain function was measured in 5 patients with clinically diagnosed Steele-Richardson-Olszewski syndrome using positron emission tomography and tracers of dopamine metabolism, blood flow and oxygen metabolism. A global decrease in blood flow and oxygen utilization compared with normal values was found but the decrease was more marked in the frontal regions. The degree of impairment in oxygen utilization in the frontal region paralleled roughly the duration of the disease. Blood flow was impaired to a greater extent than oxygen utilization, resulting in raised oxygen extraction. This can partially be explained by a lower pCO2 in the patients. Alternatively it may imply involvement of brain vasculature in the pathophysiology of the disease in addition to neuronal degeneration. Striatal dopamine formation and storage, as indicated by L-(18F)fluorodopa uptake, was significantly decreased compared with control values. The severity of this decrease paralleled the degree of reduction in frontal cerebral blood flow. The results suggest that the impairment of cerebral function in Steele-Richardson-Olszewski syndrome is determined to a large extent by brainstem pathology.
Mots-clé
Adult, Brain/metabolism, Cerebrovascular Circulation, Dihydroxyphenylalanine/analogs & derivatives, Dihydroxyphenylalanine/diagnostic use, Energy Metabolism, Fluorine Radioisotopes/diagnostic use, Humans, Middle Aged, Oxygen Consumption, Supranuclear Palsy, Progressive/metabolism, Supranuclear Palsy, Progressive/physiopathology, Tomography, Emission-Computed
Pubmed
Création de la notice
08/10/2011 14:21
Dernière modification de la notice
20/08/2019 14:45
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