Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.

Détails

Ressource 1Télécharger: BIB_867956295262.P001.pdf (578.80 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_867956295262
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.
Périodique
Investigative Ophthalmology and Visual Science
Auteur(s)
Behar-Cohen F.F., Goureau O., D'Hermies F., Courtois Y.
ISSN
0146-0404 (Print)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
37
Numéro
8
Pages
1711-1715
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
PURPOSE: To evaluate the effect of intraocular administration of nitric oxide (NO) donors in the rabbit eye on intraocular pressure (IOP), inflammation, and toxicity.
METHODS: Intravitreal and intracameral injections of two NO donors, SIN-1 and SNAP, and SIN-1C and BSS were performed. Clinical examination, IOP measurements, protein evaluation in aqueous humor, and histologic analysis of the ocular globes were realized. Nitric oxide release was demonstrated by nitrite production in the aqueous humor and in the vitreous using the Griess reaction.
RESULTS: The drastic decrease of IOP, observed after a single NO donor injection, was correlated directly with nitrite production and, thus, to NO release. Injection of inactive metabolite of SIN-1, SIN-1C, which is not able to release NO, did not modulate IOP. When administered in the aqueous humor or in the vitreous, NO did not diffuse from one segment of the eye to another. No inflammation or histologic damage was observed as a result of a single NO donor administration.
CONCLUSIONS: Nitric oxide is implicated directly in the regulation of IOP and its acute, and massive release into the rabbit eye did not induce inflammation or other growth toxic effects on the ocular tissues.
Mots-clé
Acetonitriles/pharmacology, Animals, Aqueous Humor/drug effects, Aqueous Humor/metabolism, Eye/metabolism, Eye Proteins/metabolism, Female, Injections, Intraocular Pressure/drug effects, Molsidomine/analogs & derivatives, Molsidomine/pharmacology, Morpholines/pharmacology, Nitric Oxide/pharmacology, Nitrites/metabolism, Ocular Hypotension/chemically induced, Penicillamine/analogs & derivatives, Penicillamine/pharmacology, Rabbits, S-Nitroso-N-Acetylpenicillamine, Vasodilator Agents/pharmacology, Vitreous Body/drug effects, Vitreous Body/metabolism
Pubmed
Web of science
Création de la notice
10/04/2014 13:31
Dernière modification de la notice
20/08/2019 14:45
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