Fat poetry: a kingdom for PPAR gamma.

Détails

ID Serval
serval:BIB_865F4582DE63
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Fat poetry: a kingdom for PPAR gamma.
Périodique
Cell Research
Auteur(s)
Anghel S.I., Wahli W.
ISSN
1748-7838[electronic], 1001-0602[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
17
Numéro
6
Pages
486-511
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma), which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARgamma agonists are therapeutic agents used in the treatment of type 2 diabetes.This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARgamma in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARgamma modulators.
Mots-clé
Adipose Tissue/metabolism, Adipose Tissue/physiology, Animals, Energy Metabolism/physiology, Homeostasis/physiology, Humans, Obesity/metabolism, PPAR gamma/metabolism, PPAR gamma/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:04
Dernière modification de la notice
20/08/2019 14:45
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