Lausannevirus, a giant amoebal virus encoding histone doublets.

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_865129BE5DA2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lausannevirus, a giant amoebal virus encoding histone doublets.
Périodique
Environmental Microbiology
Auteur⸱e⸱s
Thomas V., Bertelli C., Collyn F., Casson N., Telenti A., Goesmann A., Croxatto A., Greub G.
ISSN
1462-2920 (Electronic)
ISSN-L
1462-2912
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
13
Numéro
6
Pages
1454-1466
Langue
anglais
Résumé
Large viruses infecting algae or amoebae belong to the NucleoCytoplasmic Large DNA Viruses (NCLDV) and present genotypic and phenotypic characteristics that have raised major interest among microbiologists. Here, we describe a new large virus discovered in Acanthamoeba castellanii co-culture of an environmental sample. The virus, referred to as Lausannevirus, has a very limited host range, infecting Acanthamoeba spp. but being unable to infect other amoebae and mammalian cell lines tested. Within A. castellanii, this icosahedral virus of about 200 nm exhibits a development cycle similar to Mimivirus, with an eclipse phase 2 h post infection and a logarithmic growth leading to amoebal lysis in less than 24 h. The 346 kb Lausannevirus genome presents similarities with the recently described Marseillevirus, sharing 89% of genes, and thus belongs to the same family as confirmed by core gene phylogeny. Interestingly, Lausannevirus and Marseillevirus genomes both encode three proteins with predicted histone folds, including two histone doublets, that present similarities to eukaryotic and archaeal histones. The discovery of Lausannevirus and the analysis of its genome provide some insight in the evolution of these large amoebae-infecting viruses.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/09/2011 18:54
Dernière modification de la notice
20/08/2019 14:45
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