Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations.

Détails

Ressource 1Télécharger: cancers-12-03539-v2.pdf (1321.57 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_86378DB83C45
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations.
Périodique
Cancers
Auteur(s)
Tomita S., Kikuti Y.Y., Carreras J., Sakai R., Takata K., Yoshino T., Bea S., Campo E., Missiaglia E., Bouilly J., Letourneau A., de Leval L., Nakamura N.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Statut éditorial
Publié
Date de publication
27/11/2020
Peer-reviewed
Oui
Volume
12
Numéro
12
Pages
3539
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare primary T-cell lymphoma of the digestive tract derived from intraepithelial lymphocytes and characterized by an aggressive clinical course. In this study, nine cases of Japanese MEITL were analyzed by targeted Next Generation Sequencing (NGS) and immunohistochemistry and were integrated with previously reported whole-genome copy number microarray-based assay data. The highlight of our findings is that all cases showed alterations of the tumor suppressor gene SETD2 by mutations and/or loss of the corresponding 3p21 locus. We also demonstrated that all cases showed mutations in one or more genes of JAK/STAT pathway. Therefore, the combination of epigenetic deregulation and cell signaling activation represent major oncogenic events in the pathogenesis of MEITL in Asian MEITL, similar to Western MEITL.
Mots-clé
Cancer Research, Oncology, JAK/STAT pathway, MEITL, NGS, SETD2, copy-number changes, genome profile, mutational landscape
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/12/2020 8:06
Dernière modification de la notice
03/02/2021 7:09
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