Role of the circadian clock gene Per2 in adaptation to cold temperature.

Détails

ID Serval
serval:BIB_860E27AEE288
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Role of the circadian clock gene Per2 in adaptation to cold temperature.
Périodique
Molecular Metabolism
Auteur(s)
Chappuis S., Ripperger J.A., Schnell A., Rando G., Jud C., Wahli W., Albrecht U.
ISSN
2212-8778 (Electronic)
ISSN-L
2212-8778
Statut éditorial
Publié
Date de publication
2013
Volume
2
Numéro
3
Pages
184-193
Langue
anglais
Résumé
Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1) and its activation by free fatty acids. Here we show that mice without functional Period2 (Per2) were cold sensitive because their adaptive thermogenesis system was less efficient. Upon cold-exposure, Heat shock factor 1 (HSF1) induced Per2 in the BAT. Subsequently, PER2 as a co-activator of PPARα increased expression of Ucp1. PER2 also increased Fatty acid binding protein 3 (Fabp3), a protein important to transport free fatty acids from the plasma to mitochondria to activate UCP1. Hence, in BAT PER2 is important for the coordination of the molecular response of mice exposed to cold by synchronizing UCP1 expression and its activation.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/02/2014 15:16
Dernière modification de la notice
20/08/2019 14:45
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