Time course changes of the mechanical properties of the carotid artery in renal hypertensive rats.

Détails

ID Serval
serval:BIB_85FF4D0F2F3E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Time course changes of the mechanical properties of the carotid artery in renal hypertensive rats.
Périodique
Hypertension
Auteur(s)
Zanchi A., Wiesel P., Aubert J.F., Brunner H.R., Hayoz D.
ISSN
0194-911X
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
1199-1203
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
Distensibility of the carotid artery is not altered 2 weeks after renal artery clipping despite adaptive vascular hypertrophy related to hypertension. The purpose of this study was to assess arterial wall behavior with hypertension persisting for a longer period. Male Wistar rats were examined 1, 5, 9, and 24 weeks after renal artery clipping (two-kidney, one clip renal hypertension; n = 40) or after sham operation (n = 39). Mean blood pressure increased significantly to 132 +/- 4, 143 +/- 4, 153 +/- 4, and 144 +/- 4 versus 98 +/- 2, 107 +/- 2, 115 +/- 3, and 108 +/- 3 mm Hg, respectively, in 1-, 5-, 9-, and 24-week hypertensive rats and age-matched controls. Cardiac and vascular hypertrophy increased in parallel and were correlated to mean blood pressure. Wall stress at mean blood pressure did not differ between the hypertensive and normotensive groups (3.79 +/- 0.24, 4.60 +/- 0.34, 4.49 +/- 0.27, and 4.14 +/- 0.28 versus 3.15 +/- 0.12, 4.14 +/- 0.25, 4.80 +/- 0.28, and 4.69 +/- 0.32 10(3) dyne/cm2, respectively, in 1-, 5-, 9-, and 24-week hypertensive rats and age-matched controls). Distensibility-pressure data from the two groups fell on a common curve for all study periods. The intrinsic properties of the wall constituents were similar in controls and hypertensive rats at 1 and 5 weeks. However, the arteries became stiffer in the 9- and 24-week hypertensive rats, as illustrated by a shift to higher levels of the incremental elastic modulus-stress curve. Wall stress remains constant at mean blood pressure as a result of the increase in wall tissue mass. With time, even though the distensibility-pressure curve is not shifted downward, the thickened wall becomes stiffer in the hypertensive rats, which may predispose them to accelerated alterations of the wall material.
Mots-clé
Animals, Blood Pressure, Cardiomegaly, Carotid Arteries, Hypertension, Renovascular, Hypertrophy, Male, Rats, Rats, Wistar, Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 16:11
Dernière modification de la notice
20/08/2019 14:45
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