Development of the Crohn's disease digestive damage score, the Lémann score.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_85CC2D3D845B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Development of the Crohn's disease digestive damage score, the Lémann score.
Périodique
Inflammatory Bowel Diseases
Auteur(s)
Pariente B., Cosnes J., Danese S., Sandborn W.J., Lewin M., Fletcher J.G., Chowers Y., D'Haens G., Feagan B.G., Hibi T., Hommes D.W., Irvine E.J., Kamm M.A., Loftus E.V., Louis E., Michetti P., Munkholm P., Oresland T., Panés J., Peyrin-Biroulet L., Reinisch W., Sands B.E., Schoelmerich J., Schreiber S., Tilg H., Travis S., van Assche G., Vecchi M., Mary J.Y., Colombel J.F., Lémann M.
ISSN
1536-4844 (Electronic)
ISSN-L
1078-0998
Statut éditorial
Publié
Date de publication
2011
Volume
17
Numéro
6
Pages
1415-1422
Langue
anglais
Résumé
Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lémann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage. (Inflamm Bowel Dis 2011).
Pubmed
Web of science
Création de la notice
30/05/2011 9:54
Dernière modification de la notice
20/08/2019 14:45
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