Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma.
Détails
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_85C6D66E54AC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma.
Périodique
Annals of clinical and translational neurology
ISSN
2328-9503 (Print)
ISSN-L
2328-9503
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
5
Numéro
9
Pages
1016-1024
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients.
Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset.
Multivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68).
Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.
Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset.
Multivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68).
Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/09/2018 9:59
Dernière modification de la notice
20/08/2019 15:45