Decrease of thalamic gray matter following limb amputation.

Détails

ID Serval
serval:BIB_85BD3A10B9C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Decrease of thalamic gray matter following limb amputation.
Périodique
Neuroimage
Auteur⸱e⸱s
Draganski B., Moser T., Lummel N., Gänssbauer S., Bogdahn U., Haas F., May A.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
31
Numéro
3
Pages
951-957
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Modern neuroscience has elucidated general mechanisms underlying the functional plasticity of the adult mammalian brain after limb deafferentation. However, little is known about possible structural alterations following amputation and chronic loss of afferent input in humans. Using voxel-based morphometry (VBM), based on high-resolution magnetic resonance images, we investigated the brain structure of 28 volunteers with unilateral limb amputation and compared them to healthy controls. Subjects with limb amputation exhibited a decrease in gray matter of the posterolateral thalamus contralateral to the side of the amputation. The thalamic gray matter differences were positively correlated with the time span after the amputation but not with the frequency or magnitude of coexisting phantom pain. Phantom limb pain was unrelated to thalamic structural variations, but was positively correlated to a decrease in brain areas related to the processing of pain. No gray matter increase was detected. The unilateral thalamic differences may reflect a structural correlate of the loss of afferent input as a secondary change following deafferentation.
Mots-clé
Adolescent, Adult, Afferent Pathways/pathology, Aged, Amputation, Atrophy, Dominance, Cerebral/physiology, Extremities/innervation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mathematical Computing, Middle Aged, Neuronal Plasticity/physiology, Pain Measurement, Phantom Limb/pathology, Reference Values, Statistics as Topic, Thalamus/pathology
Pubmed
Web of science
Création de la notice
18/01/2013 17:55
Dernière modification de la notice
20/08/2019 14:45
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