Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor)

Détails

ID Serval
serval:BIB_85B491F475B1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor)
Périodique
Gene
Auteur⸱e⸱s
Shakhov  A. N., Kuprash  D. V., Azizov  M. M., Jongeneel  C. V., Nedospasov  S. A.
ISSN
0378-1119 (Print)
Statut éditorial
Publié
Date de publication
11/1990
Volume
95
Numéro
2
Pages
215-21
Notes
Journal Article --- Old month value: Nov 15
Résumé
The genes coding for 20-kDa lymphotoxin (TNF-beta) and tumor necrosis factor (TNF-alpha) have been cloned from a rabbit genomic library. The two genes are tandemly arranged and separated by only 1 kb of DNA, as previously observed in human and mouse genomes. We have sequenced the entire rabbit lymphotoxin-encoding gene and inferred the primary structure of rabbit TNF-beta, whose cDNA is not yet cloned. We also analysed the upstream sequences of the rabbit TNF-beta and TNF-alpha genes and identified a number of potential binding sites for known nuclear transcription factors, and in particular several putative kappa B-type sequences.
Mots-clé
Amino Acid Sequence Animals Base Sequence Binding Sites Cloning, Molecular Consensus Sequence Gene Library Genes Humans Lymphotoxin-alpha/*genetics Molecular Sequence Data Rabbits Regulatory Sequences, Nucleic Acid Restriction Mapping Sequence Alignment Transcription Factors/metabolism Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Création de la notice
24/01/2008 15:39
Dernière modification de la notice
20/08/2019 14:45
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