Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type.

Détails

Ressource 1Télécharger: 32679859_BIB_85A502AF6D6C.pdf (2333.70 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_85A502AF6D6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type.
Périodique
Cancers
Auteur(s)
Priebe V., Sartori G., Napoli S., Chung EYL, Cascione L., Kwee I., Arribas A.J., Mensah A.A., Rinaldi A., Ponzoni M., Zucca E., Rossi D., Efremov D., Lenz G., Thome M., Bertoni F.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Statut éditorial
Publié
Date de publication
15/07/2020
Peer-reviewed
Oui
Volume
12
Numéro
7
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Diffuse large B cell lymphoma (DLBCL) is a heterogenous disease that has been distinguished into at least two major molecular entities, the germinal center-like B cell (GCB) DLBCL and activated-like B cell (ABC) DLBCL, based on transcriptome expression profiling. A recurrent ch11q24.3 gain is observed in roughly a fourth of DLBCL cases resulting in the overexpression of two ETS transcription factor family members, ETS1 and FLI1. Here, we knocked down ETS1 expression by siRNA and analyzed expression changes integrating them with ChIP-seq data to identify genes directly regulated by ETS1. ETS1 silencing affected expression of genes involved in B cell signaling activation, B cell differentiation, cell cycle, and immune processes. Integration of RNA-Seq (RNA sequencing) data and ChIP-Seq (chromatin immunoprecipitation sequencing) identified 97 genes as bona fide, positively regulated direct targets of ETS1 in ABC-DLBCL. Among these was the Fc receptor for IgM, FCMR (also known as FAIM3 or Toso), which showed higher expression in ABC- than GCB-DLBCL clinical specimens. These findings show that ETS1 is contributing to the lymphomagenesis in a subset of DLBCL and identifies FCMR as a novel target of ETS1, predominantly expressed in ABC-DLBCL.
Mots-clé
BCL6, ETS1, PRDM1, diffuse large B cell lymphoma
Pubmed
Open Access
Oui
Création de la notice
24/07/2020 13:15
Dernière modification de la notice
15/01/2021 7:10
Données d'usage