PTH and 1.25 vitamin D response to a low-calcium diet is associated with bone mineral density in renal stone formers.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_857327EBD763
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
PTH and 1.25 vitamin D response to a low-calcium diet is associated with bone mineral density in renal stone formers.
Périodique
Nephrology, Dialysis, Transplantation
Auteur(s)
Pasch A., Frey F.J., Eisenberger U., Mohaupt M.G., Bonny O.
ISSN
1460-2385[electronic], 0931-0509[linking]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
23
Numéro
8
Pages
2563-2570
Langue
anglais
Résumé
BACKGROUND: Renal calcium stones and hypercalciuria are associated with a reduced bone mineral density (BMD). Therefore, the effect of changes in calcium homeostasis is of interest for both stones and bones. We hypothesized that the response of calciuria, parathyroid hormone (PTH) and 1.25 vitamin D to changes in dietary calcium might be related to BMD. METHODS: A single-centre prospective interventional study of 94 hyper- and non-hypercalciuric calcium stone formers consecutively retrieved from our stone clinic. The patients were investigated on a free-choice diet, a low-calcium diet, while fasting and after an oral calcium load. Patient groups were defined according to lumbar BMD (z-score) obtained by dual X-ray absorptiometry (group 1: z-score <-0.5, n = 30; group 2: z-score -0.5-0.5, n = 36; group 3: z-score >0.5, n = 28). The effect of the dietary interventions on calciuria, 1.25 vitamin D and PTH in relation to BMD was measured. RESULTS: An inverse relationship between BMD and calciuria was observed on all four calcium intakes (P = 0.009). On a free-choice diet, 1.25 vitamin D and PTH levels were identical in the three patient groups. However, the relative responses of 1.25 vitamin D and PTH to the low-calcium diet were opposite in the three groups with the highest increase of 1.25 vitamin D in group 1 and the lowest in group 3, whereas PTH increase was most pronounced in group 3 and least in group 1. CONCLUSION: Calcium stone formers with a low lumbar BMD exhibit a blunted response of PTH release and an apparently overshooting production of 1.25 vitamin D following a low-calcium diet.
Mots-clé
Adult, Bone Density/physiology, Calcitriol/blood, Calcium/blood, Calcium/urine, Calcium, Dietary/administration & dosage, Cohort Studies, Female, Humans, Hypercalciuria/complications, Hypercalciuria/metabolism, Kidney Calculi/complications, Kidney Calculi/metabolism, Lumbar Vertebrae, Male, Middle Aged, Parathyroid Hormone/blood, Prospective Studies
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/03/2009 12:44
Dernière modification de la notice
20/08/2019 15:44
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