Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study.

Détails

ID Serval
serval:BIB_8567E2D655DC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study.
Périodique
Clinical Endocrinology
Auteur(s)
Trimboli P., Cremonini N., Ceriani L., Saggiorato E., Guidobaldi L., Romanelli F., Ventura C., Laurenti O., Messuti I., Solaroli E., Madaio R., Bongiovanni M., Orlandi F., Crescenzi A., Valabrega S., Giovanella L.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
2014
Volume
80
Numéro
1
Pages
135-140
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter StudyPublication Status: ppublish
Résumé
OBJECTIVE: Only few studies analysed the capability of cytology in detecting medullary thyroid cancer (MTC), and they reported a low accuracy of this diagnostic technique. Recently, calcitonin (CT) measurement in aspiration needle washout (FNA-CT) of thyroid and neck lesions has been reported as a sensitive tool for MTC. The aim of this study is to compare the sensitivity of FNA-CT and cytology in detecting MTC and to assess a cut-off value of FNA-CT for clinical practice.
PATIENTS: Thirty-eight MTC lesions from 36 patients were retrospectively studied, diagnosed and treated in four different centres. Furthermore, 52 nonmedullary lesions from subjects undergone biopsy following increased serum CT were collected as a control group.
RESULTS: Cytology detected MTC in 21/37 lesions with 56·8% sensitivity. The median FNA-CT value was 2000 pg/ml (range 58-10 000 pg/ml) in MTC and 2·7 pg/ml (range <2-13 pg/ml) in controls (P < 0·001). Using a cut-off of 39·6 pg/ml, MTC lesions could be identified with 100% sensitivity and specificity. As the most important finding, 14 histologically proved MTC lesions could be detected by FNA-CT, despite they were cytologically diagnosed as benign or nonconclusive.
CONCLUSIONS: This study shows, as the first in a multicentre series, that FNA-CT sensitivity is higher than that of cytology in diagnosing MTC. To avoid false-negative MTC by cytology, CT measurement in aspiration needle washout is to be performed in all patients undergoing biopsy following high serum CT.
Mots-clé
Adult, Aged, Biopsy, Fine-Needle/methods, Calcitonin/analysis, Cytological Techniques/methods, Female, Humans, Male, Middle Aged, Retrospective Studies, Sensitivity and Specificity, Thyroid Gland/metabolism, Thyroid Gland/pathology, Thyroid Neoplasms/diagnosis, Thyroid Neoplasms/metabolism, Thyroid Nodule/diagnosis, Thyroid Nodule/metabolism
Pubmed
Web of science
Création de la notice
21/01/2015 17:04
Dernière modification de la notice
20/08/2019 15:44
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