Endothelium-derived relaxing factor and protection against contractions induced by histamine and serotonin in the human internal mammary artery and in the saphenous vein

Détails

ID Serval
serval:BIB_84E471AB25A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Endothelium-derived relaxing factor and protection against contractions induced by histamine and serotonin in the human internal mammary artery and in the saphenous vein
Périodique
Circulation
Auteur(s)
Yang  Z. H., Diederich  D., Schneider  K., Siebenmann  R., Stulz  P., von Segesser  L., Turina  M., Buhler  F. R., Luscher  T. F.
ISSN
0009-7322
Statut éditorial
Publié
Date de publication
10/1989
Peer-reviewed
Oui
Volume
80
Numéro
4
Pages
1041-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
We investigated the release of endothelium-derived relaxing factor (EDRF) in response to serotonin and histamine in the human internal mammary artery and saphenous vein. The arteries and veins were obtained intraoperatively and were suspended in organ chambers to record isometric tension. In mammary arteries, histamine (10(-8) to 3 X 10(-6) M) induced relaxations in rings with (70 +/- 5%, IC50, 6.5 +/- 0.2) but not without endothelium (p less than 0.005 for rings with compared with those without endothelium, n = 7-10). The response was inhibited by methylene blue or hemoglobin, but not meclofenamate, and, therefore, EDRF was delineated as the mediator. Because chlorpheniramine but not cimetidine inhibited the response, EDRF was released by the H1-histaminergic receptor (n = 5-8). In contrast, in saphenous veins, histamine caused only weak or absent endothelium-dependent relaxations, but contractions were enhanced in rings with endothelium (p less than 0.05, n = 6). Serotonin did not induce endothelium-dependent relaxations, but contractions were markedly greater in veins compared with arteries (p less than 0.005, n = 6). The endothelium inhibited the maximal contraction to serotonin in arteries (p less than 0.034) but not in veins. Thus, EDRF protects against contractions induced by histamine and serotonin in the mammary artery but not in the saphenous vein. This may be important for improved graft function and patency of the artery compared with that of the vein.
Mots-clé
Endothelium, Vascular/physiology Histamine/*pharmacology Humans Mammary Arteries/*drug effects/physiology Nitric Oxide/*physiology Saphenous Vein/*drug effects/physiology Serotonin/*pharmacology Thoracic Arteries *Vasoconstriction
Pubmed
Web of science
Création de la notice
14/02/2008 14:18
Dernière modification de la notice
20/08/2019 14:44
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