Interaction of alpha-melanotropin with central dopamine systems: role of hormonal state and molecular structure

Détails

ID Serval
serval:BIB_848FAE0A3875
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interaction of alpha-melanotropin with central dopamine systems: role of hormonal state and molecular structure
Périodique
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften
Auteur⸱e⸱s
Lichtensteiger W., Monnet F.
ISSN
0036-7494
Statut éditorial
Publié
Date de publication
1978
Volume
34
Numéro
1-3
Pages
197-208
Langue
anglais
Résumé
The tubero-infundibular and nigrostriatal DA neurone systems of rats respond to systemic (i.p.) injection of alpha-MSH (2-100 microgram/kg). The response of the tubero-infundibular (arcuate) DA neurones, an increase in cellular fluorescence intensity which can be interpreted as a sign of increased neuronal activity, is essentially the same in males, estrogen-progesterone-pretreated ovariectomized females and hypophysectomized males, whereas the type of response elicited by alpha-MSH in the nigral DA neurones depends upon the hormonal state of the animal. Differences between the two DA neurone groups exist also with regard to the effects of peptide fragments containing the two active sites of the alpha-MSH molecule. Results of lesion experiments in the lower brainstem (area postrema) and of blockade of muscarinic mechanisms by atropine further point to differences in the mechanisms underlying the peptide effects on the two neurone systems. The reaction of the tubero-infundibular DA system (which controls the pars intermedia of the pituitary) can be considered to reflect the activation of a feedback mechanism on MSH secretion, while the functional counterpart of the changes observed in the nigral system remains unknown at the present time.
Mots-clé
Adrenergic Fibers/*drug effects Adrenocorticotropic Hormone/pharmacology Animals Atropine/pharmacology Castration Dopamine/*metabolism Dose-Response Relationship, Drug Estrogens/pharmacology Female Hypophysectomy Male Melanocyte-Stimulating Hormones/blood/*pharmacology Molecular Conformation Peptide Fragments Pituitary Gland, Anterior/innervation Progesterone/pharmacology Rats Receptors, Muscarinic/drug effects Substantia Nigra/drug effects
Pubmed
Web of science
Création de la notice
10/02/2009 14:05
Dernière modification de la notice
20/08/2019 15:44
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