Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model.

Détails

ID Serval
serval:BIB_8448C0E69BC8
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Institution
Titre
Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model.
Titre du livre
Advances in Experimental Medicine and Biology
Auteur⸱e⸱s
Zehn D., Wherry E.J.
Editeur
Springer
ISBN
0065-2598 (Print)
Statut éditorial
Publié
Date de publication
2015
Volume
850
Pages
137-152
Langue
anglais
Résumé
The development of dysfunctional or exhausted T cells is characteristic of immune responses to chronic viral infections and cancer. Exhausted T cells are defined by reduced effector function, sustained upregulation of multiple inhibitory receptors, an altered transcriptional program and perturbations of normal memory development and homeostasis. This review focuses on (a) illustrating milestone discoveries that led to our present understanding of T cell exhaustion, (b) summarizing recent developments in the field, and (c) identifying new challenges for translational research. Exhausted T cells are now recognized as key therapeutic targets in human infections and cancer. Much of our knowledge of the clinically relevant process of exhaustion derives from studies in the mouse model of Lymphocytic choriomeningitis virus (LCMV) infection. Studies using this model have formed the foundation for our understanding of human T cell memory and exhaustion. We will use this example to discuss recent advances in our understanding of T cell exhaustion and illustrate the value of integrated mouse and human studies and will emphasize the benefits of bi-directional mouse-to-human and human-to-mouse research approaches.
Pubmed
Web of science
Création de la notice
19/10/2015 13:05
Dernière modification de la notice
20/08/2019 14:43
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