Sample size and statistical power in the hierarchical analysis of variance: applications in morphometry of the nervous system.

Détails

ID Serval
serval:BIB_8403F643BA50
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sample size and statistical power in the hierarchical analysis of variance: applications in morphometry of the nervous system.
Périodique
Journal of neuroscience methods
Auteur(s)
Leuba G., Jeanprêtre N., Kraftsik R., Fritschy J.M.
ISSN
0165-0270
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
29
Numéro
3
Pages
231-239
Langue
anglais
Résumé
Analysis of variance is commonly used in morphometry in order to ascertain differences in parameters between several populations. Failure to detect significant differences between populations (type II error) may be due to suboptimal sampling and lead to erroneous conclusions; the concept of statistical power allows one to avoid such failures by means of an adequate sampling. Several examples are given in the morphometry of the nervous system, showing the use of the power of a hierarchical analysis of variance test for the choice of appropriate sample and subsample sizes. In the first case chosen, neuronal densities in the human visual cortex, we find the number of observations to be of little effect. For dendritic spine densities in the visual cortex of mice and humans, the effect is somewhat larger. A substantial effect is shown in our last example, dendritic segmental lengths in monkey lateral geniculate nucleus. It is in the nature of the hierarchical model that sample size is always more important than subsample size. The relative weight to be attributed to subsample size thus depends on the relative magnitude of the between observations variance compared to the between individuals variance.
Mots-clé
Aging, Analysis of Variance, Animals, Callitrichinae, Cell Count, Dendrites, Geniculate Bodies, Humans, Mice, Nervous System, Neurons, Visual Cortex
Pubmed
Web of science
Création de la notice
30/03/2009 11:48
Dernière modification de la notice
20/08/2019 15:43
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