SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.

Détails

ID Serval
serval:BIB_83E0F4CADB1E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.
Périodique
Developmental Dynamics
Auteur(s)
van Bezooijen R.L., Deruiter M.C., Vilain N., Monteiro R.M., Visser A., van der Wee-Pals L., van Munsteren C.J., Hogendoorn P.C., Aguet M., Mummery C.L., Papapoulos S.E., Ten Dijke P., Löwik C.W.
ISSN
1058-8388 (Print)
ISSN-L
1058-8388
Statut éditorial
Publié
Date de publication
2007
Volume
236
Numéro
2
Pages
606-612
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or beta-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression.
Mots-clé
Animals, Arteries/metabolism, Bone Morphogenetic Proteins/metabolism, Cardiovascular System/embryology, Cardiovascular System/growth & development, Gene Expression Regulation, Developmental, Genetic Markers, Glycoproteins, In Situ Hybridization, Mice, Muscle, Smooth/metabolism, Signal Transduction/genetics, Wnt Proteins/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
20/08/2019 15:43
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