Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_839B7BEE48F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit.
Périodique
Brain pathology
Auteur(s)
Prada Jardim A., Liu J., Baber J., Michalak Z., Reeves C., Ellis M., Novy J., de Tisi J., McEvoy A., Miserocchi A., Targas Yacubian E.M., Sisodiya S., Thompson P., Thom M.
ISSN
1750-3639 (Electronic)
ISSN-L
1015-6305
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
28
Numéro
2
Pages
143-154
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Neuropathological subtypes of hippocampal sclerosis (HS) in temporal lobe epilepsy (The 2013 International League Against Epilepsy classification) are based on the qualitative assessment of patterns of neuronal loss with NeuN. In practice, some cases appear indeterminate between type 1 (CA1 and CA4 loss) and type 2 HS (CA1 loss) and we predicted that MAP2 would enable a more stringent classification. HS subtypes, as well as the accompanying alteration of axonal networks, regenerative capacity and neurodegeneration have been previously correlated with outcome and memory deficits and may provide prognostic clinical information. We selected 92 cases: 52 type 1 HS, 15 type 2 HS, 18 indeterminate-HS and 7 no-HS. Quantitative analysis was carried out on NeuN and MAP2 stained sections and a labeling index (LI) calculated for six hippocampal subfields. We also evaluated hippocampal regenerative activity (MCM2, nestin, olig2, calbindin), degeneration (AT8/phosphorylated tau) and mossy-fiber pathway re-organization (ZnT3). Pathology measures were correlated with clinical epilepsy history, memory and naming test scores and postoperative outcomes, at 1 year following surgery. MAP2 LI in indeterminate-HS was statistically similar to type 2 HS but this clustering was not shown with NeuN. Moderate verbal and visual memory deficits were noted in all HS types, including 54% and 69% of type 2 HS. Memory deficits correlated with several pathology factors including lower NeuN or MAP2 LI in CA4, CA1, dentate gyrus (DG) and subiculum and poor preservation of the mossy fiber pathway. Decline in memory at 1 year associated with AT8 labeling in the subiculum and DG but not HS type. We conclude that MAP2 is a helpful addition in the classification of HS in some cases. Classification of HS subtype, however, did not significantly correlate with outcome or pre- or postoperative memory dysfunction, which was associated with multiple pathology factors including hippocampal axonal pathways, regenerative capacity and degenerative changes.

Mots-clé
hippocampal sclerosis, memory, mossy fiber sprouting, temporal lobe epilepsy
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/04/2017 17:39
Dernière modification de la notice
20/08/2019 15:43
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