Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
Détails
ID Serval
serval:BIB_8329
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
Périodique
Bioorganic & Medicinal Chemistry Letters
ISSN
0960-894X
Statut éditorial
Publié
Date de publication
1998
Volume
8
Numéro
13
Pages
1687-1688
Langue
anglais
Notes
Publication types: Journal Article
Résumé
A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)-2',3',4'- trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.
Mots-clé
Administration, Oral, Anticoagulants/chemistry, Anticoagulants/pharmacology, Benzopyrans/chemistry, Benzopyrans/pharmacology, Hydrolysis, Thrombosis/drug therapy, Veins/pathology
OAI-PMH
Pubmed
Création de la notice
19/11/2007 11:37
Dernière modification de la notice
20/08/2019 15:43
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