Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women

Détails

ID Serval
serval:BIB_830A9C8B76BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women
Périodique
Diabetes
Auteur(s)
Giusti  V., Verdumo  C., Suter  M., Gaillard  R. C., Burckhardt  P., Pralong  F.
ISSN
0012-1797 (Print)
Statut éditorial
Publié
Date de publication
07/2003
Volume
52
Numéro
7
Pages
1673-6
Notes
Journal Article --- Old month value: Jul
Résumé
Data regarding the expression of peroxisome proliferator-activated receptor (PPAR)-gamma(1) and PPAR-gamma(2) in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are conflicting. To clarify this issue, we studied 50 women who had a BMI >35 kg/m(2) were undergoing gastric reduction surgery. Phenotyping included recording of anthropometric parameters and of a biological profile. Quantification of the expression of PPAR-gamma(1) and PPAR-gamma(2) in samples of VAT and SAT was performed by real-time RT-PCR. In both SAT and VAT, the level of expression of PPAR-gamma(2) were >20-fold that of PPAR-gamma(1) (P < 0.001 for both). However, only PPAR-gamma(1) was differentially expressed, its levels in SAT being 216 +/- 34% those in VAT (P < 0.001). In a stepwise, multivariate regression analysis, the levels of PPAR-gamma(1) in both SAT and VAT were the major determinants of waist circumference (R(2) = 21% for both; P < 0.01). Finally, leptin but not PPARs appeared as the single parameter explaining the largest part of the variability of BMI in our cohort of patients (R(2) = 22%, P < 0.001). These results are consistent with the putative roles of PPAR-gamma(1) and PPAR-gamma(2) in carbohydrate metabolism and energy homeostasis, respectively. As such, they constitute an important step toward the identification of potential targets for novel therapeutic strategies in the fields of obesity.
Mots-clé
Adipose Tissue/*metabolism/pathology Adult Biopsy Body Constitution Female Humans Obesity/*genetics/pathology Protein Isoforms/genetics RNA, Messenger/genetics Receptors, Cytoplasmic and Nuclear/*genetics Reverse Transcriptase Polymerase Chain Reaction Skin Transcription Factors/*genetics Viscera
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:26
Dernière modification de la notice
20/08/2019 15:43
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