Nitric oxide mediates the blood pressure response to mental stress in humans.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_82F4ACB2B571
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nitric oxide mediates the blood pressure response to mental stress in humans.
Périodique
Swiss Medical Weekly
Auteur(s)
Trueb L., Lepori M., Duplain H., Scherrer U., Sartori C.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
2012
Volume
142
Pages
13627
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: epublish
Résumé
OBJECTIVE: Nitric oxide (NO) regulates arterial pressure by modulating peripheral vascular tone and sympathetic vasoconstrictor outflow. NO synthesis is impaired in several major cardiovascular disease states. Loss of NO-induced vasodilator tone and restraint on sympathetic outflow could result in exaggerated pressor responses to mental stress.
METHODS: We, therefore, compared the sympathetic (muscle sympathetic nerve activity) and haemodynamic responses to mental stress performed during saline infusion and systemic inhibition of NO-synthase by NG-monomethyl-L-arginine (L-NMMA) infusion.
RESULTS: The major finding was that mental stress which during saline infusion increased sympathetic nerve activity by ~50 percent and mean arterial pressure by ~15 percent had no detectable sympathoexcitatory and pressor effect during L-NMMA infusion. These findings were not related to a generalised impairment of the haemodynamic and/or sympathetic responsiveness by L-NMMA, since the pressor and sympathetic nerve responses to immersion of the hand in ice water were preserved during L-NMMA infusion.
CONCLUSION: Mental stress causes pressor and sympathoexcitatory effects in humans that are mediated by NO. These findings are consistent with the new concept that, in contrast to what has been generally assumed, under some circumstances, NO has a blood pressure raising action in vivo.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2012 11:07
Dernière modification de la notice
20/08/2019 15:42
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