The evolution of gene expression levels in mammalian organs.

Détails

ID Serval
serval:BIB_82F2C6964F5B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The evolution of gene expression levels in mammalian organs.
Périodique
Nature
Auteur(s)
Brawand D., Soumillon M., Necsulea A., Julien P., Csárdi G., Harrigan P., Weier M., Liechti A., Aximu-Petri A., Kircher M., Albert F.W., Zeller U., Khaitovich P., Grützner F., Bergmann S., Nielsen R., Pääbo S., Kaessmann H.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2011
Volume
478
Numéro
7369
Pages
343-348
Langue
anglais
Résumé
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals.
Mots-clé
Animals, Evolution, Molecular, Gene Expression Profiling, Humans, Phylogeny, Principal Component Analysis, RNA, Messenger/genetics, X Chromosome/genetics
Pubmed
Web of science
Création de la notice
17/01/2012 13:56
Dernière modification de la notice
20/08/2019 14:42
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