Periventricular [(11)C]flumazenil binding for predicting postoperative outcome in individual patients with temporal lobe epilepsy and hippocampal sclerosis
Détails
ID Serval
serval:BIB_821B450FEF8B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Periventricular [(11)C]flumazenil binding for predicting postoperative outcome in individual patients with temporal lobe epilepsy and hippocampal sclerosis
Périodique
Neuroimage Clin
ISSN
2213-1582 (Print)
ISSN-L
2213-1582
Statut éditorial
Publié
Date de publication
2013
Volume
3
Pages
242-8
Langue
anglais
Notes
Yankam Njiwa, Josiane
Bouvard, Sandrine
Catenoix, Helene
Mauguiere, Francois
Ryvlin, Philippe
Hammers, Alexander
eng
Netherlands
Neuroimage Clin. 2013 Sep 3;3:242-8. doi: 10.1016/j.nicl.2013.07.008. eCollection 2013.
Bouvard, Sandrine
Catenoix, Helene
Mauguiere, Francois
Ryvlin, Philippe
Hammers, Alexander
eng
Netherlands
Neuroimage Clin. 2013 Sep 3;3:242-8. doi: 10.1016/j.nicl.2013.07.008. eCollection 2013.
Résumé
A third of patients with intractable temporal lobe epilepsy and hippocampal sclerosis (HS) are not seizure free (NSF) after surgery. Increased periventricular [(11)C]flumazenil (FMZ) binding, reflecting heterotopic neuron concentration, has been described as one predictor of NSF outcome at the group level. We aimed to replicate this finding in an independent larger cohort and investigated whether NSF outcome can be predicted in individuals. Preoperative [(11)C]FMZ summed radioactivity images were available for 16 patients with HS and 41 controls. Images were analyzed using SPM8, explicitly including the white matter, and correction for global radioactivity via group-specific ANCOVA. Periventricular increases were assessed with a mask and different cutoffs for distinguishing NSF and seizure free (SF) patients. NSF patients had increased [(11)C]FMZ binding around the posterior horn of the ventricles ipsilaterally (z = 2.53) and contralaterally (z = 4.44) to the seizure focus compared with SF patients. Compared with controls, SF patients had fewer periventricular increases (two clusters, total volume 0.87 cm(3), zmax = 3.8) than NSF patients (two ipsilateral and three contralateral clusters, 6.15 cm(3), zmax = 4.8). In individuals and at optimized cutoffs, five (63%) of eight NSF patients and one (13%) of eight SF patients showed periventricular increases compared with controls (accuracy 75%). Only one (2%) of the 41 controls had increases at the same cutoff. The association between periventricular [(11)C]FMZ increases and NSF outcome after temporal lobe resection for HS has been confirmed in an independent cohort on simple summed activity images. [(11)C]FMZ-PET may be useful for individual preoperative counseling with clinically relevant accuracy.
Mots-clé
Hippocampal sclerosis, Mesial temporal lobe epilepsy, Outcome, Periventricular increases, White matter, [11C]Flumazenil-PET
Pubmed
Open Access
Oui
Création de la notice
29/11/2018 13:37
Dernière modification de la notice
20/08/2019 15:42