Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease.
Détails
ID Serval
serval:BIB_820F4708FB65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease.
Périodique
Clinical microbiology reviews
ISSN
1098-6618 (Electronic)
ISSN-L
0893-8512
Statut éditorial
Publié
Date de publication
13/06/2024
Peer-reviewed
Oui
Volume
37
Numéro
2
Pages
e0007423
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
SUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, and fungicidal mechanism(s) are urgently needed. Here, we provide a comprehensive review of novel antifungal agents, with both improved known mechanisms of actions and new antifungal classes, currently in clinical development for treating invasive yeast, mold (filamentous fungi), Pneumocystis jirovecii infections, and dimorphic fungi (endemic mycoses). We further focus on inhaled antifungals and the role of immunotherapy in tackling fungal infections, and the specific PK/pharmacodynamic profiles, tissue distributions as well as drug-drug interactions of novel antifungals. Finally, we review antifungal resistance mechanisms, the role of use of antifungal pesticides in agriculture as drivers of drug resistance, and detail detection methods for antifungal resistance.
Mots-clé
Antifungal Agents/therapeutic use, Antifungal Agents/pharmacokinetics, Antifungal Agents/pharmacology, Humans, Invasive Fungal Infections/drug therapy, Invasive Fungal Infections/microbiology, Drug Resistance, Fungal, Fungi/drug effects, Animals, Treatment Outcome, fungal disease
Pubmed
Web of science
Création de la notice
15/04/2024 12:39
Dernière modification de la notice
18/06/2024 6:09