HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells
Détails
ID Serval
serval:BIB_81FC323D58B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells
Périodique
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
05/2005
Volume
102
Numéro
20
Pages
7239-44
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 17
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 17
Résumé
Functional and phenotypic characterization of virus-specific CD8 T cells against cytomegalovirus, Epstein-Barr virus, influenza (flu), and HIV-1 were performed on the basis of the ability of CD8 T cells to secrete IFN-gamma and IL-2, to proliferate, and to express CD45RA and CCR7. Two functional distinct populations of CD8 T cells were identified: (i) dual IFN-gamma/IL-2-secreting cells and (ii) single IFN-gamma-secreting cells. Virus-specific IFN-gamma/IL-2-secreting CD8 T cells were CD45RA-CCR7-, whereas single IFN-gamma CD8 T cells were either CD45RA-CCR7- or CD45RA+CCR7-. The proportion of virus-specific IFN-gamma/IL-2-secreting CD8 T cells correlated with that of proliferating CD8 T cells, and the loss of HIV-1-specific IL-2-secreting CD8 T cells was associated with that of HIV-1-specific CD8 T cell proliferation. Substantial proliferation of virus-specific CD8 T cells (including HIV-1-specific CD8 T cells) was also observed in CD4 T cell-depleted populations or after stimulation with MHC class I tetramer-peptide complexes. IL-2 was the factor responsible for the CD4-independent CD8 T cell proliferation. These results indicate that IFN-gamma/IL-2-secreting CD8 T cells may promote antigen-specific proliferation of CD8 T cells even in the absence of helper CD4 T cells.
Mots-clé
Antigens, CD4/immunology
Antigens, CD45/metabolism
CD8-Positive T-Lymphocytes/immunology/*secretion/virology
*Cell Proliferation
Cytomegalovirus/immunology
Flow Cytometry
HIV Infections/*immunology
*Hiv-1
Herpesvirus 4, Human/immunology
Humans
Interferon Type II/*secretion
Interleukin-2/*secretion
Orthomyxoviridae/immunology
Receptors, Chemokine/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:00
Dernière modification de la notice
20/08/2019 14:42