Radiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL: étude prospective de phase II [Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck]
Détails
ID Serval
serval:BIB_81AA14D0107B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Radiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL: étude prospective de phase II [Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck]
Périodique
Cancer Radiothérapie
ISSN
1278-3218
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
7
Numéro
4
Pages
231-236
Langue
français
Notes
Publication types: Clinical Trial ; Clinical Trial, Phase II ; English Abstract ; Journal Article - Publication Status: ppublish
Résumé
PURPOSE: To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. RESULTS: According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. CONCLUSION: The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable.
Mots-clé
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Combined Modality Therapy, Dose Fractionation, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Survival Analysis, Treatment Outcome, Weight Loss
Pubmed
Création de la notice
28/01/2008 8:39
Dernière modification de la notice
20/08/2019 14:41