Effects of perinatal, late foetal, and early embryonic insults on the cardiovascular phenotype in experimental animal models and humans.

Détails

ID Serval
serval:BIB_8189859A996F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Effects of perinatal, late foetal, and early embryonic insults on the cardiovascular phenotype in experimental animal models and humans.
Périodique
VASA. Zeitschrift fur Gefasskrankheiten
Auteur⸱e⸱s
Meister T.A., Rexhaj E., Rimoldi S.F., Scherrer U., Sartori C.
ISSN
0301-1526 (Print)
ISSN-L
0301-1526
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
45
Numéro
6
Pages
439-449
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Cardiovascular diseases are the main cause of mortality and morbidity in Western countries, but the underlying mechanisms are still poorly understood. Genetic polymorphisms, once thought to represent a major determinant of cardiovascular risk, individually and collectively, only explain a tiny fraction of phenotypic variation and disease risk in humans. It is now clear that non-genetic factors, i.e., factors that modify gene activity without changing the DNA sequence and that are sensitive to the environment can cause important alterations of the cardiovascular phenotype in experimental animal models and humans. Here, we will review recent studies demonstrating that distinct pathological events during the perinatal (transient perinatal hypoxemia), late foetal (preeclampsia), and early embryonic (assisted reproductive technologies) periods induce profound alterations of the cardiovascular phenotype in humans and experimental animals. Moreover, we will provide evidence that epigenetic modifications are contributing importantly to this problem and are conferring the potential for its transmission to subsequent generations.

Pubmed
Création de la notice
09/09/2016 10:06
Dernière modification de la notice
20/08/2019 15:41
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