EDGAR 2.0: an enhanced software platform for comparative gene content analyses.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_8105EEB44781
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
EDGAR 2.0: an enhanced software platform for comparative gene content analyses.
Périodique
Nucleic Acids Research
Auteur(s)
Blom J., Kreis J., Spänig S., Juhre T., Bertelli C., Ernst C., Goesmann A.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
44
Numéro
W1
Pages
W22-W28
Langue
anglais
Résumé
The rapidly increasing availability of microbial genome sequences has led to a growing demand for bioinformatics software tools that support the functional analysis based on the comparison of closely related genomes. By utilizing comparative approaches on gene level it is possible to gain insights into the core genes which represent the set of shared features for a set of organisms under study. Vice versa singleton genes can be identified to elucidate the specific properties of an individual genome. Since initial publication, the EDGAR platform has become one of the most established software tools in the field of comparative genomics. Over the last years, the software has been continuously improved and a large number of new analysis features have been added. For the new version, EDGAR 2.0, the gene orthology estimation approach was newly designed and completely re-implemented. Among other new features, EDGAR 2.0 provides extended phylogenetic analysis features like AAI (Average Amino Acid Identity) and ANI (Average Nucleotide Identity) matrices, genome set size statistics and modernized visualizations like interactive synteny plots or Venn diagrams. Thereby, the software supports a quick and user-friendly survey of evolutionary relationships between microbial genomes and simplifies the process of obtaining new biological insights into their differential gene content. All features are offered to the scientific community via a web-based and therefore platform-independent user interface, which allows easy browsing of precomputed datasets. The web server is accessible at http://edgar.computational.bio.
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/05/2016 18:55
Dernière modification de la notice
20/08/2019 15:41
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