Ultraviolet radiation-induced skin tumors in a South American opossum (Monodelphis domestica)

Détails

ID Serval
serval:BIB_80FF170FB169
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Ultraviolet radiation-induced skin tumors in a South American opossum (Monodelphis domestica)
Périodique
Veterinary Pathology
Auteur(s)
Kusewitt  D. F., Applegate  L. A., Ley  R. D.
ISSN
0300-9858 (Print)
Statut éditorial
Publié
Date de publication
1991
Volume
28
Numéro
1
Pages
55-65
Notes
DA - 19910523
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Research Support, U.S. Gov't, P.H.S
SB - IM
Résumé
A total of 19 male and 21 female South American opossums (Monodelphis domestica) were exposed to 250 J/m2 ultraviolet radiation from FS-40 sunlamps (280-400 nm) three times weekly for 70 weeks. The backs of the opossums were shaved as necessary to remove hair. In order to prevent photoreactivation of ultraviolet radiation-induced pyrimidine dimers by the light-dependent photolyase enzyme of the opossum, ultraviolet radiation-exposed opossums were housed under red lights (600-800 nm). The opossum photolyase requires light in the 320-450 nm range for its activity. Twenty-nine control opossums (14 males and 15 females) were irradiated by fluorescent lights with emission spectra primarily in the visible light range (320-700 nm); these control opossums were also housed under red lights, and their backs were also shaved to remove hair. No skin tumors were observed in control opossums, while ultraviolet radiation-exposed opossums developed a variety of hyperplastic and neoplastic skin lesions on the backs and on a single ear. Hyperplastic lesions included foci of epithelial hyperplasia, dermal fibroplasia, and focal proliferation of dermal melanocytes. A total of 20 ultraviolet radiation-exposed opossums (50%) developed skin tumors, and 13 opossums (32.5%) had more than a single tumor. Epithelial tumors included 25 papillomas, four keratoacanthomas, seven carcinomas in situ, three microinvasive squamous cell carcinomas, two invasive squamous cell carcinomas, and a single basal cell tumor. Ten dermal spindle cell tumors also occurred; most of these appeared to be fibrosarcomas. Two benign melanomas and one malignant melanoma were observed
Mots-clé
adverse effects/Animals/Carcinoma in Situ/Carcinoma,Basal Cell/Carcinoma,Squamous Cell/Female/Fibrosarcoma/Hyperplasia/Keratoacanthoma/Light/Longevity/Male/Melanoma/Neoplasms,Radiation-Induced/Opossums/Papilloma/pathology/Pyrimidine Dimers/radiation effects/Skin/Skin Neoplasms/Ultraviolet Rays/veterinary
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/02/2008 18:33
Dernière modification de la notice
20/08/2019 15:41
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