GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

Détails

ID Serval
serval:BIB_80CDDFA660E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.
Périodique
Cell Reports
Auteur⸱e⸱s
Karaca M., Frigerio F., Migrenne S., Martin-Levilain J., Skytt D.M., Pajecka K., Martin-Del-Rio R., Gruetter R., Tamarit-Rodriguez J., Waagepetersen H.S., Magnan C., Maechler P.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
10/2015
Peer-reviewed
Oui
Volume
13
Numéro
2
Pages
365-375
Langue
anglais
Résumé
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glutamate and may use it through oxidative glutamate dehydrogenase (GDH) activity. Here, we investigated the significance of glutamate as energy substrate for the brain. Upon glutamate exposure, astrocytes generated ATP in a GDH-dependent way. The observed lack of glutamate oxidation in brain-specific GDH null CnsGlud1(-/-) mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK in the hypothalamus. This induced changes in the autonomous nervous system balance, with increased sympathetic activity promoting hepatic glucose production and mobilization of substrates reshaping peripheral energy stores. Our data reveal the importance of glutamate as necessary energy substrate for the brain and the role of central GDH in the regulation of whole-body energy homeostasis.
Pubmed
Open Access
Oui
Création de la notice
06/10/2015 7:26
Dernière modification de la notice
20/08/2019 14:41
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