CD40 ligand has potent antiviral activity.

Détails

ID Serval
serval:BIB_807D663E9954
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CD40 ligand has potent antiviral activity.
Périodique
Nature Medicine
Auteur(s)
Ruby J., Bluethmann H., Aguet M., Ramshaw I.A.
ISSN
1078-8956 (Print)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
1995
Volume
1
Numéro
5
Pages
437-441
Langue
anglais
Résumé
For B cells to make antibodies against most antigens, they require help from T cells. T cell help is delivered as two signals to the B cell, one of which is via CD40 and the other can be through receptors for any of a variety of soluble cytokines. We have constructed recombinant vaccinia viruses that express the ligand for CD40 and have shown that the growth of these viruses is dramatically controlled in vivo, even in mice that lack T or B cells. In this paper, we also describe our attempts to analyse the CD40 ligand-mediated antiviral activity by studying the clearance of these viruses in mice that are deficient in important antiviral mechanisms. Thus, the antiviral activity of CD40L may represent a surprising and potent effector mechanism of T cells activated during a virus infection.
Mots-clé
Animals, Antigens, CD40/immunology, Antigens, CD40/pharmacology, Antiviral Agents/immunology, B-Lymphocytes/immunology, Cells, Cultured, Humans, Interferon-gamma/immunology, Ligands, Mice, Mice, Nude, Recombinant Proteins/immunology, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/immunology, Vaccinia virus/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 15:41
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