Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller.

Détails

Ressource 1Télécharger: BIB_805C9F9E02AA.P001.pdf (1021.40 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_805C9F9E02AA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller.
Périodique
Plos One
Auteur⸱e⸱s
Pernas M., Casado C., Arcones C., Llano A., Sánchez-Merino V., Mothe B., Vicario J.L., Grau E., Ruiz L., Sánchez J., Telenti A., Yuste E., Brander C., Galíndez C.L.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Volume
7
Numéro
2
Pages
e31928
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient.¦METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs.¦CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/05/2012 9:09
Dernière modification de la notice
20/08/2019 14:40
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