Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors

Détails

ID Serval
serval:BIB_8037F6DE8496
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
Périodique
Regulatory Peptides
Auteur⸱e⸱s
Pralong  F. P., Voirol  M., Giacomini  M., Gaillard  R. C., Grouzmann  E.
ISSN
0167-0115 (Print)
Statut éditorial
Publié
Date de publication
11/2000
Volume
95
Numéro
1-3
Pages
47-52
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 24
Résumé
Pubertal development results from the coordinate secretion of gonadotropin-releasing hormone (GnRH) by hypothalamic GnRH neurons. Central administration of neuropeptide Y (NPY) to prepubertal rats can indefinitely delay sexual maturation by inhibiting this GnRH secretion. The aim of the present study was to further investigate the physiological role of NPY in pubertal development, and to assess the potential involvement of its Y1 receptor subtype in this setting. The timing of pubertal development was determined in juvenile female rats receiving chronic i.c.v. infusion of a specific Y1 receptor antagonist (BIBP 3226), and compared with controls. Although treatment with BIBP 3226 did not affect the age at vaginal opening, animals receiving the Y1 antagonist experienced a quicker progression through puberty, corroborated by a significant increase in pituitary luteinizing hormone content. This effect of BIBP3226 on the gonadotrope axis occurred without apparent toxicity, but was accompanied by a transient decrease in body weight gain on the first day of treatment, suggesting an effect on appetite. Together, our results add to the evidence in favour of a role for NPY in the onset of puberty. They are entirely consistent with the proposed inhibition exerted by endogenous hypothalamic NPY before the onset of pubertal development. They also suggest that the Y1 subtype of NPY receptors is involved in this effect.
Mots-clé
Aging Animals Arginine/*analogs & derivatives/pharmacology Body Weight/drug effects Female Hypothalamus/growth & development/metabolism Luteinizing Hormone/blood/metabolism Neuropeptide Y/metabolism Pituitary Gland/growth & development/metabolism Rats Rats, Wistar Receptors, Neuropeptide Y/*antagonists & inhibitors/physiology Sexual Maturation/drug effects/*physiology Vagina/drug effects/growth & development Weight Gain/drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 16:26
Dernière modification de la notice
20/08/2019 14:40
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