A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes
Détails
ID Serval
serval:BIB_803014F803A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes
Périodique
International Journal of Cancer
ISSN
0020-7136 (Print)
Statut éditorial
Publié
Date de publication
12/1999
Volume
83
Numéro
6
Pages
755-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 10
Research Support, Non-U.S. Gov't --- Old month value: Dec 10
Résumé
We previously described different cytotoxic T lymphocyte (CTL) clones isolated from the blood lymphocytes of a melanoma patient after in vitro stimulation with autologous tumor cells. These CTL clones recognized at least 2 distinct antigens on the melanoma cells. Here, we show that one of them consists of a peptide derived from tyrosinase and presented by HLA-B35. The peptide is 9 amino acids long and has the sequence LPSSADVEF. It can be presented by the 2 major B35 allelic subtypes, B*3501 and B*3503. As HLA-B35 is one of the most frequent HLA-B specificities, being present in about 20% of Caucasian individuals, it may be a useful target for peptide-based immunotherapy of melanoma.
Mots-clé
Alleles
Amino Acid Sequence
Animals
B-Lymphocytes
COS Cells
Cell Line, Transformed
Cytotoxicity, Immunologic
HLA-B35 Antigen/genetics/*immunology
Herpesvirus 4, Human
Humans
Melanoma/immunology
Monophenol Monooxygenase/chemistry/*immunology
Peptide Fragments/chemistry/*immunology
Recombinant Proteins/immunology
T-Lymphocytes, Cytotoxic/*immunology
Transfection
Tumor Cells, Cultured
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 10:36
Dernière modification de la notice
20/08/2019 15:40