Synaptic modulation by astrocytes via Ca(2+)-dependent glutamate release

Détails

ID Serval
serval:BIB_80089A85A6BC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Synaptic modulation by astrocytes via Ca(2+)-dependent glutamate release
Périodique
Neuroscience
Auteur(s)
Santello  M., Volterra  A.
ISSN
0306-4522 (Print)
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
158
Numéro
1
Pages
253-9
Langue
anglais
Notes
Journal article --- Old month value: Mar 22 --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18455880
Résumé
In the past 15 years the classical view that astrocytes play a relatively passive role in brain function has been overturned and it has become increasingly clear that signaling between neurons and astrocytes may play a crucial role in the information processing that the brain carries out. This new view stems from two seminal observations made in the early 1990s: 1. astrocytes respond to neurotransmitters released during synaptic activity with elevation of their intracellular Ca(2+) concentration ([Ca(2+)](i)); 2. astrocytes release chemical transmitters, including glutamate, in response to [Ca(2+)](i) elevations. The simultaneous recognition that astrocytes sense neuronal activity and release neuroactive agents has been instrumental for understanding previously unknown roles of these cells in the control of synapse formation, function and plasticity. These findings open a conceptual revolution, leading to rethink how brain communication works, as they imply that information travels (and is processed) not just in the neuronal circuitry but in an expanded neuron-glia network. In this review we critically discuss the available information concerning: 1. the characteristics of the astrocytic Ca(2+) responses to synaptic activity; 2. the basis of Ca(2+)-dependent glutamate exocytosis from astrocytes; 3. the modes of action of astrocytic glutamate on synaptic function.
Mots-clé
glia, gliotransmitters, neuron-astrocyte interactions, synaptic transmission, glutamate exocytosis, calcium signaling
Pubmed
Web of science
Création de la notice
13/05/2008 14:57
Dernière modification de la notice
20/08/2019 15:40
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